Etchevers Heather C, Couly Gérard, Le Douarin Nicole M
Institute of Cellular and Molecular Embryology, College of France, Nogent-sur-Marne, France.
Trends Cardiovasc Med. 2002 Oct;12(7):299-304. doi: 10.1016/s1050-1738(02)00178-0.
The branchial and dorsal cephalic vascular sectors correspond to the blood vessels contained within evolutionarily recent and ancestral parts of the head, respectively. Recent work demonstrates that neural crest cells (NCCs) provide the pericytes, and connective and smooth muscle cells to the entire branchial sector in an ordered fashion. Initial NCC position is transposed to the vascular distal-to-proximal axis, explaining why circumscribed cephalic vascular anomalies are often associated with reproducible malformations in head tissues derived from the neural crest. Unlike the rest of the central nervous system, the forebrain requires mesenchyme-containing vascular-competent NCCs to survive during embryogenesis and beyond.
鳃血管和头部背侧血管区域分别对应于头部进化上较新和祖先部分内包含的血管。最近的研究表明，神经嵴细胞（NCCs）以有序的方式为整个鳃区提供周细胞、结缔组织和平滑肌细胞。最初的NCC位置被转换到血管的远端到近端轴，这解释了为什么局限性头部血管异常通常与源自神经嵴的头部组织中可重复出现的畸形相关。与中枢神经系统的其他部分不同，前脑在胚胎发育及以后需要含有间充质的具有血管生成能力的NCCs才能存活。
