Boucherie H, Bégueret J, Bernet J
J Gen Microbiol. 1976 Jan;92(1):59-66. doi: 10.1099/00221287-92-1-59.
In Podospora anserina, protoplasmic incompatibility due to interactions between non-allelic genes was suppressed by the effect of mutations in two modifier genes, mod-I and mod-2. It is shown that mod-I and mod-2 are involved in the production of three specific proteins, a phenoloxidase and two previously identified proteases (Bégueret & Bernet 1973 a) which are associated with the phenomenon of protoplasmic disintegration. These enzymes, whose messengers are normallly latent during vegetative growth, appear at this stage of the life cycle only as a consequence of incompatible gene interactions. The mode-I and mod-2 genes and each of the five incompatibility loci involved in non-allelic incompatibility systems also participate in the formation of the protoperithecia. This pleiotropic effect suggests that protoplasmic incompatibility is a deviation in the normal physiological processes of protoperithecial formation.
在嗜热栖热放线菌中，非等位基因间相互作用导致的原生质体不亲和性受到两个修饰基因mod-1和mod-2突变的抑制。研究表明，mod-1和mod-2参与三种特定蛋白质的产生，一种酚氧化酶和两种先前鉴定的蛋白酶（贝盖雷和贝内特，1973年a），它们与原生质体解体现象有关。这些酶的信使在营养生长期间通常是潜伏的，仅在生命周期的这个阶段由于不亲和基因相互作用而出现。参与非等位不亲和系统的mod-1和mod-2基因以及五个不亲和位点中的每一个也参与原囊壳的形成。这种多效性效应表明，原生质体不亲和性是原囊壳形成正常生理过程中的一种偏差。
