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Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells.

作者信息

Iizasa Himashi, Bae Sun-Hye, Asashima Tomoko, Kitano Tomohide, Matsunaga Noriko, Terasaki Tetsuya, Kang Young-Sook, Nakashima Emi

机构信息

Department of Pharmaceutics, Kyoritsu College of Pharmacy, 1-5-30 Shiba-koen, Minato-ku, Tokyo 105-8512, Japan.

出版信息

Pharm Res. 2002 Nov;19(11):1757-60. doi: 10.1023/a:1020921818105.

DOI:10.1023/a:1020921818105
PMID:12458684
Abstract
摘要

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Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells.
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3
Occludin as a possible determinant of tight junction permeability in endothelial cells.闭合蛋白作为内皮细胞紧密连接通透性的一个可能决定因素。
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Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures.闭合蛋白是一种与紧密连接相关的整合膜蛋白，其过表达会诱导形成带有紧密连接样结构的细胞内多层小体。
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Engineering the folding pathway of insect cells: generation of a stably transformed insect cell line showing improved folding of a recombinant membrane protein.设计昆虫细胞的折叠途径：生成一种稳定转化的昆虫细胞系，该细胞系能改善重组膜蛋白的折叠。
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本文引用的文献

1
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.白细胞介素-2受体β亚基依赖性和非依赖性对肠上皮紧密连接的调节
J Biol Chem. 2001 Sep 21;276(38):35571-80. doi: 10.1074/jbc.M106013200. Epub 2001 Jul 20.
2
Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats.
Pharm Res. 2001 Jan;18(1):9-15. doi: 10.1023/a:1011062307374.
3
mRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting.条件性永生化大鼠脑微血管内皮细胞系的mRNA表达及转运特性；一种用于药物靶向的新型体外血脑屏障模型
J Drug Target. 2000;8(6):357-70. doi: 10.3109/10611860008997912.
4
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.炎性疼痛会改变血脑屏障的通透性和紧密连接蛋白的表达。
Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1241-8. doi: 10.1152/ajpheart.2001.280.3.H1241.
5
Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions.血管生成素-1在体外是一种抗通透性和抗炎因子，作用于细胞连接。
Circ Res. 2000 Sep 29;87(7):603-7. doi: 10.1161/01.res.87.7.603.
6
Cloning and kinetics of expression of Brucella abortus heat shock proteins by baculovirus recombinants.杆状病毒重组体对流产布鲁氏菌热休克蛋白的克隆及表达动力学
Vet Microbiol. 2000 Jul 31;75(2):199-204. doi: 10.1016/s0378-1135(00)00203-0.
7
Angiopoietin-1 protects the adult vasculature against plasma leakage.
Nat Med. 2000 Apr;6(4):460-3. doi: 10.1038/74725.
8
Prolactin, alone or in combination with glucocorticoids, enhances tight junction formation and expression of the tight junction protein occludin in mammary cells.催乳素单独或与糖皮质激素联合使用时，可增强乳腺细胞中紧密连接的形成以及紧密连接蛋白闭合蛋白的表达。
Mol Cell Endocrinol. 1999 Oct 25;156(1-2):55-61. doi: 10.1016/s0303-7207(99)00145-8.
9
Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity.
J Biol Chem. 1999 Oct 15;274(42):30196-201. doi: 10.1074/jbc.274.42.30196.
10
Angiopoietin-1 is an apoptosis survival factor for endothelial cells.血管生成素-1是内皮细胞的一种凋亡存活因子。
FEBS Lett. 1999 Apr 9;448(2-3):249-53. doi: 10.1016/s0014-5793(99)00378-6.