Hass F J, Lee P S, Lourenco R V
J Nucl Med. 1976 Feb;17(02):122-5.
This paper describes a method of tagging iron oxide aerosol particles with 99mTc. The tagging is achieved by reducing the heptavalent pertechnetate form to its reduced state using stannous chloride in a nitrogen atmosphere. Tests by ultracentrifugation and paper chromatography shown that the tagging is virtually complete. Separation of the tag from the particles in sputum is shown to be minimal. Monodisperse aerosols of the tagged particles are produced with a spinning-disk atomizer. (Deposition and clearance of the particles in the airways and lungs is easily followed by scintigraphy.) Factors affecting attachment and separation of the tag are discussed.
本文描述了一种用99mTc标记氧化铁气溶胶颗粒的方法。标记是通过在氮气气氛中用氯化亚锡将七价高锝酸盐形式还原到其还原态来实现的。超速离心和纸色谱测试表明标记几乎是完全的。已证明标记物与痰液中颗粒的分离极少。用旋转盘雾化器产生标记颗粒的单分散气溶胶。（通过闪烁扫描很容易跟踪颗粒在气道和肺部的沉积和清除情况。）讨论了影响标记物附着和分离的因素。
