Zuber A, Dirnagl K, Drexel H
Med Klin. 1976 Oct 15;71(42):1788-92.
The topical distribution of inhaled aerosols produced by customary jet nebulizers has been measured scintigraphically. Corrections for absorption and stray effects with experimentally determined factors allowed to evaluate the quantities of deposited aerosol for the head, chest and abdominal regions. Highest aerosol intakes were found with slow inhalation through the mouth. The deposition decreased at higher respiration rates with a further diminution when inhalation takes place through the nose. The individuals had characteristic patterns of aerosol distribution resulting in more pronounced deposition differences than those caused by the mode of inhalation.
已通过闪烁扫描法测量了传统喷射雾化器产生的吸入气雾剂的局部分布。利用实验确定的因素对吸收和杂散效应进行校正,从而能够评估头部、胸部和腹部区域沉积的气雾剂数量。发现通过口腔缓慢吸入时气雾剂摄入量最高。在较高呼吸频率下沉积减少,通过鼻腔吸入时沉积进一步减少。个体具有独特的气雾剂分布模式,导致沉积差异比吸入方式引起的差异更为明显。