黑曲霉毒素，一种来自黑曲霉CFR-W-105的具有自由基清除活性的新型醛糖还原酶和脂氧合酶抑制剂。
Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with Free radical scavenging activity from Aspergillus niger CFR-W-105.
作者信息
Rao K C Sekhar, Divakar S, Babu K Naveen, Rao A G Appu, Karanth N G, Sattur A P
机构信息
Fermentation Technology and Bioengineering Department, Central Food Technological Research Institute, Mysore 570 013, India.
出版信息
J Antibiot (Tokyo). 2002 Sep;55(9):789-93. doi: 10.7164/antibiotics.55.789.
An enzyme inhibitor, nigerloxin, with inhibition against soy bean lipoxygenase-I (LOX-1), rat lens aldose reductase (RLAR) as well as free radical scavenging activity was isolated from the fermented wheat bran using Aspergillus niger CFR-W-105. Its chemical structure was identified as 2-amido-3-hydroxy-6-methoxy-5-methyl-4-(prop-1'-enyl) benzoic acid by NMR and GCEIMS data. The IC50 values against LOX-1 and RLAR were found to be 79 microM and 69 microM and ED50 against 1,1-diphenyl-2-picrylhydrazyl (DPPH) was 66 microM.
利用黑曲霉CFR-W-105从发酵麦麸中分离出一种酶抑制剂——黑麦洛辛，它对大豆脂氧合酶-I（LOX-1）、大鼠晶状体醛糖还原酶（RLAR）具有抑制作用，并且具有自由基清除活性。通过核磁共振（NMR）和气相色谱-电子电离质谱（GCEIMS）数据确定其化学结构为2-氨基-3-羟基-6-甲氧基-5-甲基-4-（1'-丙烯基）苯甲酸。发现其对LOX-1和RLAR的半数抑制浓度（IC50）值分别为79微摩尔和69微摩尔，对1,1-二苯基-2-苦基肼（DPPH）的半数有效剂量（ED50）为66微摩尔。
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