Knyazeva M G, Maeder P, Kiper D C, Deonna T, Innocenti G M
Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, Switzerland.
Neural Plast. 2002;9(1):27-40. doi: 10.1155/NP.2002.27.
In one of two patients (MS and FJ) with bilateral, early-onset lesion of the primary visual cortex, Kiper et al. (2002) observed a considerable degree of functional recovery. To clarify the physiological mechanisms involved in the recovery, we used fMRI and quantitative EEG to study both patients. The fMRI investigations indicated that in both patients, isolated islands of the primary visual cortex are functioning, in the right hemisphere in MS and in the left in FJ. The functional recovery observed in MS roughly correlated with the functional maturation of interhemispheric connections and might reflect the role of corticocortical connectivity in visual perception. The functionality of interhemispheric connections was assessed by analyzing the changes in occipital inter-hemispheric coherence of EEG signals (ICoh) evoked by moving gratings. In the patient MS, this ICoh response was present at 7:11 y and was more mature at 9:2 y. In the more visually impaired patient, FJ, a consistent increase in ICoh to visual stimuli could not be obtained, possibly because of the later occurrence of the lesion.
在两名原发性视觉皮层双侧早发性病变患者（MS和FJ）中的一例，Kiper等人（2002年）观察到相当程度的功能恢复。为阐明恢复过程中涉及的生理机制，我们使用功能磁共振成像（fMRI）和定量脑电图来研究这两名患者。fMRI研究表明，在两名患者中，原发性视觉皮层的孤立岛状区域均在发挥功能，在MS患者中位于右半球，在FJ患者中位于左半球。在MS患者中观察到的功能恢复大致与半球间连接的功能成熟相关，可能反映了皮质-皮质连接在视觉感知中的作用。通过分析移动光栅诱发的脑电图信号（ICoh）枕叶半球间相干性的变化来评估半球间连接的功能。在患者MS中，这种ICoh反应在7岁11个月时出现，并在9岁2个月时更加成熟。在视力受损更严重的患者FJ中，未获得对视觉刺激的ICoh持续增加，这可能是由于病变发生较晚。
