Kiper D C, Zesiger P, Maeder P, Deonna T, Innocenti G M
Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, Switzerland.
Neural Plast. 2002;9(1):1-25. doi: 10.1155/NP.2002.1.
We analyzed the visual functions of two patients (MS, FJ) with bilateral lesion of the primary visual cortex, which occurred at gestational age 33 wk in MS and at postnatal month 7 in FJ. In both patients basic visual functions--visual acuity, contrast sensitivity, color, form, motion perception-are similarly preserved or modestly impaired. Functions requiring higher visual processing, particularly figure-ground segregation based on textural cues, are severely impaired. In MS, studied longitudinally, the deficits attenuated between the ages of 4.5 and 8 y, suggesting that the developing visual system can display a considerable degree of adaptive plasticity several years after the occurrence of a lesion. In FJ (age 18:9 to 20:6 y), who is more impaired, the recovery, if any, was less.
我们分析了两名原发性视皮层双侧病变患者（MS和FJ）的视觉功能。MS的病变发生在孕33周时，FJ的病变发生在出生后7个月。在这两名患者中，基本视觉功能——视力、对比敏感度、颜色、形状、运动感知——同样得以保留或轻度受损。需要更高视觉处理能力的功能，特别是基于纹理线索的图形-背景分离，严重受损。在纵向研究的MS患者中，4.5至8岁之间缺陷有所减轻，这表明发育中的视觉系统在病变发生几年后可以表现出相当程度的适应性可塑性。在受损更严重的FJ患者（年龄18岁9个月至20岁6个月）中，即便有恢复，程度也较小。
