Barnard R J, Aronson W J, Tymchuk C N, Ngo T H
Obes Rev. 2002 Nov;3(4):303-8. doi: 10.1046/j.1467-789x.2002.00081.x.
Insulin resistance and compensatory hyperinsulinaemia are thought to be the underlying factors in the metabolic or insulin-resistance syndrome and can be controlled by diet and exercise. Hyperinsulinaemia has been shown to have a direct effect on the live, suppressing the production of sex hormone-binding globulin (SHBG) and insulin-like growth factor-binding proteins 1 and 2 (IGFBP-1, -2) while stimulating the production of insulin-like growth factor 1 (IGF-1). These factors have been proposed to be important modulators of hormone-related cancers, such as prostate cancer. Men adopting a low-fat diet and daily exercise reduced their levels of serum insulin and IGF-1, while increasing their levels of IGFBP-1 and sex hormone-binding globulin (SHBG). Cell-culture studies with LNCaP prostate cancer cells showed apoptosis of tumour cells and a reduction in serum-stimulated cell growth in the post diet and exercise serum. These results suggest that prostate cancer may be another aspect of the insulin-resistance syndrome and that adopting a low-fat diet combined with regular exercise may reduce the risk for prostate and other hormone-related cancers. This needs to be tested with prospective studies.
胰岛素抵抗和代偿性高胰岛素血症被认为是代谢综合征或胰岛素抵抗综合征的潜在因素，可通过饮食和运动加以控制。高胰岛素血症已被证明对肝脏有直接影响，抑制性激素结合球蛋白（SHBG）以及胰岛素样生长因子结合蛋白1和2（IGFBP-1、-2）的产生，同时刺激胰岛素样生长因子1（IGF-1）的产生。这些因素被认为是激素相关癌症（如前列腺癌）的重要调节因子。采用低脂饮食并每日锻炼的男性，其血清胰岛素和IGF-1水平降低，而IGFBP-1和性激素结合球蛋白（SHBG）水平升高。对LNCaP前列腺癌细胞进行的细胞培养研究显示，在饮食和运动后的血清中，肿瘤细胞出现凋亡，血清刺激的细胞生长减少。这些结果表明，前列腺癌可能是胰岛素抵抗综合征的另一个方面，采用低脂饮食并结合规律运动可能会降低患前列腺癌和其他激素相关癌症的风险。这需要通过前瞻性研究进行验证。
