Suzuki Takashi, Moriya Takuya, Ishida Takanori, Kimura Michio, Ohuchi Noriaki, Sasano Hironobu
Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Breast Cancer. 2002;9(4):296-302. doi: 10.1007/BF02967607.
Recent studies have demonstrated that biologically active estrogens are locally produced from circulating inactive steroids in the estrogen-dependent breast carcinoma. The in situ production of estrogens in the breast carcinoma is considered to play an important role in the proliferation of breast cancer cells, especially in the postmenopausal women. Therefore, the total blockade of this pathway may inhibit estrogenic actions in breast cancer tissues and lead to an improvement in the prognosis in these patients. In this review, we describe the recent studies concerning the expression of enzymes related to intratumoral estrogen production, including aromatase, 17beta-hydroxysteroid dehydrogenase, steroid sulfatase, and estrogen sulfotransferase in human breast carcinoma tissues, and discuss the biological significance of local production of estrogens in human breast cancer.
最近的研究表明，在雌激素依赖性乳腺癌中，具有生物活性的雌激素是由循环中的无活性类固醇在局部产生的。乳腺癌中雌激素的原位产生被认为在乳腺癌细胞的增殖中起重要作用，尤其是在绝经后女性中。因此，这条途径的完全阻断可能会抑制乳腺癌组织中的雌激素作用，并改善这些患者的预后。在这篇综述中，我们描述了关于人乳腺癌组织中与肿瘤内雌激素产生相关的酶的表达的最新研究，包括芳香化酶、17β-羟基类固醇脱氢酶、类固醇硫酸酯酶和雌激素硫酸转移酶，并讨论了人乳腺癌中雌激素局部产生的生物学意义。
