雌激素和孕激素受体在乳腺癌中的作用——女性浸润性乳腺癌中雌激素和孕激素受体表达的免疫组化评估
The role of oestrogen and progesterone receptors in breast cancer - immunohistochemical evaluation of oestrogen and progesterone receptor expression in invasive breast cancer in women.
作者信息
Badowska-Kozakiewicz Anna M, Patera Janusz, Sobol Maria, Przybylski Jacek
机构信息
Department of Biophysics and Human Physiology, Medical University of Warsaw, Warsaw, Poland.
Department of Pathomorphology, Military Institute of Health Services, Warsaw, Poland.
出版信息
Contemp Oncol (Pozn). 2015;19(3):220-5. doi: 10.5114/wo.2015.51826. Epub 2015 May 28.
AIM OF THE STUDY
Expression of oestrogen and progesterone receptors is a very powerful and useful predictor. Because the response rate to hormonal treatment in breast cancer is associated with the presence of oestrogen and progesterone receptors, assessment of the receptor expression profile allows for prediction of breast cancer response to hormonal treatment. The aim of this study was to assess whether the expression of receptors for oestrogen (ER) and progesterone (PR) in the tumour tissue of patients with invasive breast cancer correlated with tumour histological type, histological grade of malignancy, tumour size, and lymph node status.
MATERIAL AND METHODS
Materials consisted of histological preparations derived from patients treated for invasive breast cancer. Evaluations were conducted with histopathological and immunohistochemical methods using suitable antibodies.
RESULTS
Among 231 cases of breast cancer 18 invasive lobular carcinomas (ILC) and 213 invasive ductal carcinomas (IDC) were diagnosed. Taking the histological type of tumour into account, oestrogen receptor-positive reaction was observed in 74.2% of IDC and 77.8% of ILC, and the positive response to PR was observed in 67.1% of IDC and 61.1% of ILC. Considering the histological grade, ER- in the largest percentage (72%) was observed in second-grade (G2) invasive carcinomas. Similarly, PR expression (75%) was found in the largest percentage in second-grade (G2) carcinomas. Based on our own studies and data from literature, it appears that the ER (+) status is an indicator of good prognosis, because it points to a less aggressive cancer, in which overall survival and disease-free time is longer in comparison with ER (-) tumours.
CONCLUSIONS
Determination of ER status may, therefore, have significant clinical value and is widely used in routine pathological diagnostics.
研究目的
雌激素和孕激素受体的表达是一种非常有力且有用的预测指标。由于乳腺癌对激素治疗的反应率与雌激素和孕激素受体的存在相关，评估受体表达谱有助于预测乳腺癌对激素治疗的反应。本研究的目的是评估浸润性乳腺癌患者肿瘤组织中雌激素受体（ER）和孕激素受体（PR）的表达是否与肿瘤组织学类型、恶性组织学分级、肿瘤大小及淋巴结状态相关。
材料与方法
材料包括来自浸润性乳腺癌患者的组织学标本。使用合适的抗体通过组织病理学和免疫组织化学方法进行评估。
结果
在231例乳腺癌病例中，诊断出18例浸润性小叶癌（ILC）和213例浸润性导管癌（IDC）。考虑肿瘤的组织学类型，74.2%的IDC和77.8%的ILC观察到雌激素受体阳性反应，67.1%的IDC和61.1%的ILC观察到对PR的阳性反应。考虑组织学分级，在二级（G2）浸润性癌中观察到ER阴性的比例最大（72%）。同样，PR表达（75%）在二级（G2）癌中所占比例最大。基于我们自己的研究和文献数据，ER（+）状态似乎是预后良好的指标，因为它表明癌症侵袭性较小，与ER（-）肿瘤相比，其总生存期和无病时间更长。
结论
因此，ER状态的测定可能具有重要的临床价值，并广泛应用于常规病理诊断。
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