N,N-二氯牛磺酸对小鼠体内血栓形成模型的抗血栓活性。

Antithrombotic activity of N,N-dichlorotaurine on mouse model of thrombosis in vivo.

作者信息

Murina M A, Fesenko O D, Sergienko V I, Chudina N A, Roshchupkin D I

机构信息

Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow.

出版信息

Bull Exp Biol Med. 2002 Jul;134(1):36-8. doi: 10.1023/a:1020600520233.

DOI:10.1023/a:1020600520233

PMID:12459864

Abstract

Intravenous injection of chloramine derivatives of amino acids and taurine reduced the mortality rate in mice with thrombosis induced by intravenous injection of ADP or collagen-epinephrine mixture. Intravenous injection of N,N-dichlorotaurine caused 50% inhibition of platelet aggregation induced by ADP and measured in the platelet-enriched plasma in vitro. The antithrombotic effect of chloramine derivatives of amino acids and taurine is related to their ability to suppress functional activity of platelets.

摘要

静脉注射氨基酸和牛磺酸的氯胺衍生物可降低因静脉注射ADP或胶原蛋白-肾上腺素混合物诱导血栓形成的小鼠的死亡率。静脉注射N，N-二氯牛磺酸可在体外富血小板血浆中对ADP诱导的血小板聚集产生50%的抑制作用。氨基酸和牛磺酸的氯胺衍生物的抗血栓作用与其抑制血小板功能活性的能力有关。