Roşca Adrian Eugen, Vlădăreanu Ana-Maria, Mirica Radu, Anghel-Timaru Cristina-Mihaela, Mititelu Alina, Popescu Bogdan Ovidiu, Căruntu Constantin, Voiculescu Suzana Elena, Gologan Şerban, Onisâi Minodora, Iordan Iuliana, Zăgrean Leon
Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Cardiology, Emergency University Hospital of Bucharest, 050098 Bucharest, Romania.
J Clin Med. 2022 Jan 27;11(3):666. doi: 10.3390/jcm11030666.
Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.
牛磺酸是一种半必需氨基酸，是人体中含量最丰富的游离氨基酸，其在血小板中的浓度比其他任何氨基酸都高六倍。它对机体非常有益，具有多种治疗作用，目前在日本已被批准用于治疗心力衰竭。体内、体外以及动物和人体研究均反复报道牛磺酸对血小板活化和聚集有抑制作用。牛磺酸在包括糖尿病、创伤性脑损伤、急性缺血性中风等在内的几种涉及血栓形成素质的病理状况中显示出有效性。由于关于血栓形成结果的人体前瞻性研究很难开展，显然需要验证现有发现，并提供有关牛磺酸及其衍生物抗血小板作用机制及其抗血栓形成潜力的新的确凿数据。牛磺酸的氯胺衍生物对血小板受体具有更高的稳定性和明显的选择性，这引发了一种假设，即它们可能代表未来潜在的抗血栓形成药物。鉴于牛磺酸及其类似物具有可接受的副作用，同时需要寻找副作用最小且具有长期作用的新型替代抗血栓药物，这种迷人的营养素及其衍生物的潜在临床相关性需要进一步考虑。
