Murina M A, Roshchupkin D I, Kravchenko N N, Petrova A O, Sergienko V I
Research Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow.
Bull Exp Biol Med. 2007 Sep;144(3):464-70. doi: 10.1007/s10517-007-0352-z.
Alanine and taurine sharply potentiate antiaggregant effects of hypochlorite on platelets in platelet-rich plasma. This effect is determined by more pronounced action of chloramine derivatives, products of interaction of added amino acids with hypochlorite. Platelets are more sensitive to the inhibitory effects of amino acid chloramine derivatives (biogenic chloramines) compared to erythrocytes and neutrophils. The antiaggregant effects of biobenic amines, as covalent platelet inhibitors, in platelet-rich plasma are characterized by their increased reaction capacity with molecular targets in cells. Quantitative parameter of this initial selectivity (ratio of rate constant of inactivation of platelet receptors to rate constant of side reaction with plasma proteins) far surpasses 1. N,N-Dichlorotaurine is a perspective antiaggreant among the studied biogenic chloramines. This agent is stable and exhibits specific pharmacological activity in all test systems, including animal model of thrombosis.
丙氨酸和牛磺酸可显著增强次氯酸盐对富血小板血浆中血小板的抗聚集作用。这种作用取决于氯胺衍生物（添加的氨基酸与次氯酸盐相互作用的产物）更显著的作用。与红细胞和中性粒细胞相比，血小板对氨基酸氯胺衍生物（生物源氯胺）的抑制作用更敏感。作为共价血小板抑制剂，生物源胺在富血小板血浆中的抗聚集作用的特点是它们与细胞中分子靶点的反应能力增强。这种初始选择性的定量参数（血小板受体失活速率常数与血浆蛋白副反应速率常数之比）远超过1。在所研究的生物源氯胺中，N,N-二氯牛磺酸是一种有前景的抗聚集剂。该制剂稳定，在所有测试系统中均表现出特定的药理活性，包括血栓形成动物模型。
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