患有胸腺淋巴瘤的AKR/JY小鼠的造血和淋巴器官
Hemopoietic and lymphoid organs in AKR/JY mice with thymic lymphoma.
作者信息
Karpova G V, Fomina T I, Abramova E V, Bel'skaya N V, Trofimova E S, Perel'muter V M
机构信息
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2002 Jul;134(1):69-72. doi: 10.1023/a:1020669007938.
Cytological and histological studies of the thymus, bone marrow, peripheral blood, spleen, and lymph nodes in 6-9-month-old AKR/JY mice showed that the risk of thymic lymphoma in these animals increased with age. Generalization of the tumor process was observed in mice aged over 8 months and first involved the spleen, then the lymph nodes, bone marrow, and liver. A case of primary lymphoma in the spleen was detected.
对6至9月龄AKR/JY小鼠的胸腺、骨髓、外周血、脾脏和淋巴结进行的细胞学和组织学研究表明，这些动物发生胸腺淋巴瘤的风险随年龄增加。在8个月以上的小鼠中观察到肿瘤进程的扩散，首先累及脾脏，然后是淋巴结、骨髓和肝脏。检测到一例脾脏原发性淋巴瘤。
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