Shisa H, Kojima A, Hiai H
Jpn J Cancer Res. 1986 Jun;77(6):568-71.
The effect of nude gene heterozygosity on spontaneous AKR thymic lymphomagenesis was studied by comparing female littermates of AKR/Ms-nu/+ and +/+. As previously reported in nude gene heterozygotes with genetic background other than AKR, AKR/Ms-nu/+ mice had a significantly smaller thymus than the +/+ littermates. Overall incidences of thymic lymphomas were comparable in the two genotypes, but the mean latent period for lymphoma development was significantly shorter in the nu/+ mice (266.3 +/- 11.6 days) than in the +/+ mice (319.3 +/- 7.9 days). Both genotypes of mice expressed a high level of XC+-ecotropic murine leukemia virus. Expression of xenotropic virus was more variable, but there was no consistent difference in onset of virus expression or in virus titer that could explain accelerated lymphomagenesis in the nude gene heterozygotes.
通过比较AKR/Ms-nu/+和+/+的雌性同窝仔鼠，研究了裸基因杂合性对自发性AKR胸腺淋巴瘤发生的影响。如先前在具有AKR以外遗传背景的裸基因杂合子中所报道的那样，AKR/Ms-nu/+小鼠的胸腺明显小于+/+同窝仔鼠。两种基因型的胸腺淋巴瘤总体发生率相当，但nu/+小鼠淋巴瘤发生的平均潜伏期（266.3±11.6天）明显短于+/+小鼠（319.3±7.9天）。两种基因型的小鼠均表达高水平的XC+-亲嗜性鼠白血病病毒。异嗜性病毒的表达更具变异性，但在病毒表达开始或病毒滴度方面没有一致的差异可以解释裸基因杂合子中淋巴瘤发生的加速。
