Lychkova A E
Department of Physiology, Russian State Medical University, Moscow.
Bull Exp Biol Med. 2002 Jul;134(1):98-9. doi: 10.1023/a:1020637528411.
Myocarditis was induced by synergic interactions of serotonin- and cholinergic nerve fibers during potentiation of vagal inhibition of cardiac activity by stimulation of the stellate ganglion. Thus modeled myocarditis was associated with increased content of serotonin and decreased concentrations of acetylcholine and catecholamines in the myocardial tissue. Blockade of 5HT3(S3) receptors in autonomic ganglia and 5HT1,2(S1,2) receptors in the myocardium improved myocardial contractility and reduced the severity of myocarditis.
