髓系同源盒蛋白Hex的下调对于正常T细胞发育至关重要。
Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.
作者信息
Mack David L, Leibowitz David S, Cooper Scott, Ramsey Heather, Broxmeyer Hal E, Hromas Robert
机构信息
Department of Medicine, the Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA.
出版信息
Immunology. 2002 Dec;107(4):444-51. doi: 10.1046/j.1365-2567.2002.01523.x.
Abstract
The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in T cells (CD11a/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.
摘要
造血同源框基因Hex（也称为Prh）在髓系细胞和B细胞中表达，但在T细胞中不表达。为了研究Hex水平是否可能在髓系与T细胞发育中发挥作用，构建了两种类型的转基因小鼠品系，每种品系的T细胞（CD11a/Hex和Lck/Hex）中均有Hex的异位表达。这两种类型的转基因小鼠在T细胞成熟方面都有相同的缺陷，表明正常的T细胞发育可能不仅依赖于淋巴特异性转录调节因子的上调，还依赖于髓系特异性转录调节因子（如Hex）的协同下调。此外，Hex的过表达显著增加了髓系祖细胞的循环，这可能解释了它在逆转录病毒诱导的小鼠白血病中的作用。
相似文献
1
Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.髓系同源盒蛋白Hex的下调对于正常T细胞发育至关重要。
Immunology. 2002 Dec;107(4):444-51. doi: 10.1046/j.1365-2567.2002.01523.x.
2
The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells.同源框基因Hex在造血前体细胞中过表达时会诱发T细胞源性淋巴瘤。
Oncogene. 2003 Oct 2;22(43):6764-73. doi: 10.1038/sj.onc.1206822.
3
HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.HEX：一种在造血过程中表达且在小鼠和人类之间保守的新型同源框基因。
Nucleic Acids Res. 1993 Mar 11;21(5):1245-9. doi: 10.1093/nar/21.5.1245.
4
The role of Hex in hemangioblast and hematopoietic development.Hex在成血管细胞和造血发育中的作用。
Methods Mol Biol. 2006;330:123-33. doi: 10.1385/1-59745-036-7:123.
5
Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.同源框基因Hex对于小鼠胚胎肝脏发育的起始以及单核细胞谱系的分化至关重要。
Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61. doi: 10.1006/bbrc.2000.3548.
6
Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex.同源框基因Hex靶向缺失小鼠的B细胞发育及功能受损。
Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):556-61. doi: 10.1073/pnas.0236979100. Epub 2003 Jan 8.
7
Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.同源框基因Cdx2的异位表达是t(12;13)(p13;q12)急性髓系白血病小鼠模型中的转化事件。
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):817-22. doi: 10.1073/pnas.0305555101. Epub 2004 Jan 12.
8
Thyroid-specific transcription factors control Hex promoter activity.甲状腺特异性转录因子控制Hex启动子活性。
Nucleic Acids Res. 2003 Apr 1;31(7):1845-52. doi: 10.1093/nar/gkg295.
9
Hex expression suggests a role in the development and function of organs derived from foregut endoderm.Hex基因的表达表明其在前肠内胚层来源器官的发育和功能中发挥作用。
Dev Dyn. 2000 Sep;219(1):84-9. doi: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1028>3.0.CO;2-5.
10
Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.Dlx和Lhx家族同源框基因在胎儿胸腺及胸腺细胞中的表达。
Gene Expr Patterns. 2004 May;4(3):315-20. doi: 10.1016/j.modgep.2003.10.003.
引用本文的文献
1
Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytokine.用一种新型腺病毒编码的 MUC1 双特异性抗体结合物和 IL-2 细胞因子克服卵巢癌腹水的效应 T 细胞耗竭。
Mol Ther. 2024 Sep 4;32(9):3114-3127. doi: 10.1016/j.ymthe.2024.06.029. Epub 2024 Jun 22.
2
The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease.造血细胞表达的同源盒转录因子：在发育、生理和疾病中的作用。
Front Immunol. 2023 Jun 16;14:1197490. doi: 10.3389/fimmu.2023.1197490. eCollection 2023.
3
The Role of NKL Homeobox Genes in T-Cell Malignancies.NKL 同源框基因在 T 细胞恶性肿瘤中的作用
Biomedicines. 2021 Nov 12;9(11):1676. doi: 10.3390/biomedicines9111676.
4
NKL Homeobox Gene VENTX Is Part of a Regulatory Network in Human Conventional Dendritic Cells.NKL 同源盒基因 VENTX 是人类常规树突状细胞调控网络的一部分。
Int J Mol Sci. 2021 May 31;22(11):5902. doi: 10.3390/ijms22115902.
5
NKL-Code in Normal and Aberrant Hematopoiesis.正常和异常造血中的NKL编码
Cancers (Basel). 2021 Apr 19;13(8):1961. doi: 10.3390/cancers13081961.
6
Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function.同源盒蛋白 Hhex 通过抑制 Foxp3 的表达和功能来负向调控 Treg 细胞。
Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25790-25799. doi: 10.1073/pnas.1907224116. Epub 2019 Dec 2.
7
Deregulated NKL Homeobox Genes in B-Cell Lymphoma.B细胞淋巴瘤中失调的NKL同源盒基因
Cancers (Basel). 2019 Nov 26;11(12):1874. doi: 10.3390/cancers11121874.
8
NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.NKL 同源盒基因在造血干细胞、T 细胞发育及 T 细胞白血病中的活性
PLoS One. 2017 Feb 2;12(2):e0171164. doi: 10.1371/journal.pone.0171164. eCollection 2017.
9
Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.在成体造血干细胞和祖细胞分化的多个阶段均需要Hhex。
Stem Cells. 2015 Aug;33(8):2628-41. doi: 10.1002/stem.2049. Epub 2015 May 27.
10
Trisomy 8 Acute Myeloid Leukemia Analysis Reveals New Insights of DNA Methylome with Identification of HHEX as Potential Diagnostic Marker.8号染色体三体急性髓系白血病分析揭示DNA甲基化组新见解并鉴定出HHEX作为潜在诊断标志物
Biomark Cancer. 2015 Jan 29;7:1-6. doi: 10.4137/BIC.S19614. eCollection 2015.
本文引用的文献
1
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.Notch1 通过调节TCR信号强度来调控CD4+和CD8+胸腺细胞的成熟。
Immunity. 2001 Mar;14(3):253-64. doi: 10.1016/s1074-7613(01)00107-8.
2
Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.同源框基因Hex对于小鼠胚胎肝脏发育的起始以及单核细胞谱系的分化至关重要。
Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61. doi: 10.1006/bbrc.2000.3548.
3
Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish.Hhex和scl在斑马鱼中协同作用，调控早期内皮细胞和血液分化。
Development. 2000 Oct;127(20):4303-13. doi: 10.1242/dev.127.20.4303.
4
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.同源框基因Hex在确定的内胚层组织中是正常前脑、肝脏和甲状腺形成所必需的。
Development. 2000 Jun;127(11):2433-45. doi: 10.1242/dev.127.11.2433.
5
Leukaemia disease genes: large-scale cloning and pathway predictions.白血病疾病基因：大规模克隆与通路预测
Nat Genet. 1999 Nov;23(3):348-53. doi: 10.1038/15531.
6
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Notch1诱导失活的小鼠中T细胞命运决定缺陷。
Immunity. 1999 May;10(5):547-58. doi: 10.1016/s1074-7613(00)80054-0.
7
Expression of the homebox gene Hex during early stages of chick embryo development.同源盒基因Hex在鸡胚发育早期阶段的表达。
Mech Dev. 1999 Jan;80(1):107-9. doi: 10.1016/s0925-4773(98)00204-4.
8
The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells.髓系锌指基因（MZF-1）可延缓维甲酸诱导的髓系白血病细胞凋亡和分化。
Leukemia. 1998 May;12(5):690-8. doi: 10.1038/sj.leu.2401005.
9
CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.未成熟胸腺细胞上的CD3连接产生适合CD8谱系定向的拮抗性样信号，与T细胞受体特异性无关。
J Exp Med. 1998 Apr 20;187(8):1249-60. doi: 10.1084/jem.187.8.1249.
10
The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number.XHex同源盒基因在血管内皮发育过程中表达：过表达导致血管内皮细胞数量增加。
Mech Dev. 1997 Aug;66(1-2):83-93. doi: 10.1016/s0925-4773(97)00092-0.
Zotero 插件