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2
The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells.同源框基因Hex在造血前体细胞中过表达时会诱发T细胞源性淋巴瘤。
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本文引用的文献

1
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.Notch1 通过调节TCR信号强度来调控CD4+和CD8+胸腺细胞的成熟。
Immunity. 2001 Mar;14(3):253-64. doi: 10.1016/s1074-7613(01)00107-8.
2
Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.同源框基因Hex对于小鼠胚胎肝脏发育的起始以及单核细胞谱系的分化至关重要。
Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61. doi: 10.1006/bbrc.2000.3548.
3
Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish.Hhex和scl在斑马鱼中协同作用，调控早期内皮细胞和血液分化。
Development. 2000 Oct;127(20):4303-13. doi: 10.1242/dev.127.20.4303.
4
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.同源框基因Hex在确定的内胚层组织中是正常前脑、肝脏和甲状腺形成所必需的。
Development. 2000 Jun;127(11):2433-45. doi: 10.1242/dev.127.11.2433.
5
Leukaemia disease genes: large-scale cloning and pathway predictions.白血病疾病基因：大规模克隆与通路预测
Nat Genet. 1999 Nov;23(3):348-53. doi: 10.1038/15531.
6
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Notch1诱导失活的小鼠中T细胞命运决定缺陷。
Immunity. 1999 May;10(5):547-58. doi: 10.1016/s1074-7613(00)80054-0.
7
Expression of the homebox gene Hex during early stages of chick embryo development.同源盒基因Hex在鸡胚发育早期阶段的表达。
Mech Dev. 1999 Jan;80(1):107-9. doi: 10.1016/s0925-4773(98)00204-4.
8
The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells.髓系锌指基因（MZF-1）可延缓维甲酸诱导的髓系白血病细胞凋亡和分化。
Leukemia. 1998 May;12(5):690-8. doi: 10.1038/sj.leu.2401005.
9
CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.未成熟胸腺细胞上的CD3连接产生适合CD8谱系定向的拮抗性样信号，与T细胞受体特异性无关。
J Exp Med. 1998 Apr 20;187(8):1249-60. doi: 10.1084/jem.187.8.1249.
10
The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number.XHex同源盒基因在血管内皮发育过程中表达：过表达导致血管内皮细胞数量增加。
Mech Dev. 1997 Aug;66(1-2):83-93. doi: 10.1016/s0925-4773(97)00092-0.

髓系同源盒蛋白Hex的下调对于正常T细胞发育至关重要。

Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.

作者信息

Mack David L, Leibowitz David S, Cooper Scott, Ramsey Heather, Broxmeyer Hal E, Hromas Robert

机构信息

Department of Medicine, the Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA.

出版信息

Immunology. 2002 Dec;107(4):444-51. doi: 10.1046/j.1365-2567.2002.01523.x.

DOI:10.1046/j.1365-2567.2002.01523.x
PMID:12460189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1782816/
Abstract

The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in T cells (CD11a/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.

摘要

造血同源框基因Hex（也称为Prh）在髓系细胞和B细胞中表达，但在T细胞中不表达。为了研究Hex水平是否可能在髓系与T细胞发育中发挥作用，构建了两种类型的转基因小鼠品系，每种品系的T细胞（CD11a/Hex和Lck/Hex）中均有Hex的异位表达。这两种类型的转基因小鼠在T细胞成熟方面都有相同的缺陷，表明正常的T细胞发育可能不仅依赖于淋巴特异性转录调节因子的上调，还依赖于髓系特异性转录调节因子（如Hex）的协同下调。此外，Hex的过表达显著增加了髓系祖细胞的循环，这可能解释了它在逆转录病毒诱导的小鼠白血病中的作用。