Verrotti Alberto, Greco Rita, Latini Giuseppe, Morgese Guido, Chiarelli Francesco
Department of Medicine, Section of Pediatrics, University of Chieti, Italy.
Epilepsia. 2002 Dec;43(12):1488-92. doi: 10.1046/j.1528-1157.2002.13002.x.
To study the markers of bone turnover in epilepsy patients in the different stages of the pubertal growth before and after the beginning of carbamazepine (CBZ) monotherapy.
We have investigated bone turnover in 60 epilepsy patients treated with CBZ. They were stratified according to pubertal stage and compared with a control group of 60 sex- and age-matched healthy children.
After 2 years of therapy, we found higher values of the serum markers of bone formation [bone alkaline phosphatase (bone ALP), osteocalcin (OC), carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP)], and of bone resorption [carboxy-terminal telopeptide of type I collagen (ICTP) and the urinary cross-linked N-telopeptides of type I collagen (NTX)] in patients than in control subjects, in presence of a normal vitamin D metabolism.
CBZ induces an increase of bone formation and of bone resorption that seems to be independent of the pubertal stage.
研究卡马西平（CBZ）单药治疗开始前后处于青春期生长不同阶段的癫痫患者的骨转换标志物。
我们调查了60例接受CBZ治疗的癫痫患者的骨转换情况。他们根据青春期阶段进行分层，并与60名年龄和性别匹配的健康儿童对照组进行比较。
治疗2年后，我们发现患者血清中骨形成标志物[骨碱性磷酸酶（骨ALP）、骨钙素（OC）、I型前胶原羧基端前肽（PICP）、III型前胶原氨基端前肽（PIIINP）]和骨吸收标志物[I型胶原羧基端肽（ICTP）和尿I型胶原交联N端肽（NTX）]的值高于对照组，且维生素D代谢正常。
CBZ诱导骨形成和骨吸收增加，这似乎与青春期阶段无关。
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