Doherty Michael J, Walting Paul J, Morita Denise C, Peterson Rich A, Miller John W, Holmes Mark D, Watson Nathaniel F
Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, Washington 98195, USA.
Epilepsia. 2002 Dec;43(12):1593-5. doi: 10.1046/j.1528-1157.2002.24002.x.
Several EEG-based studies suggest that epileptiform activity originates from the left more than the right hemisphere. In contrast, other pathophysiologies such as stroke lateralize relatively symmetrically. Study of focal slowing and other EEG abnormalities allows assessment of favoring as well as referral and interpretation bias.
The 1,331 consecutive adult EEG reports were reviewed for epileptiform discharges (EDs) and nonepileptiform focal slowing. Side of slowing or EDs, interpreting electoencephalographer, and whether the patient was undergoing long-term monitoring or routine EEG were tallied. Results were statistically analyzed.
Focal slowing occurred symmetrically; EDs favored the left hemisphere (p < 0.01).
The left hemisphere may be more prone to epileptiform abnormalities in adults, but not to the nonspecific pathophysiologic processes that cause slowing. These findings suggest that potential interpretation bias does not influence left hemispheric favoring of EDs and instead may implicate a biologic etiology.
多项基于脑电图（EEG）的研究表明，癫痫样活动起源于左侧半球的情况多于右侧半球。相比之下，其他病理生理学情况，如中风，在两侧的分布相对对称。对局灶性慢波和其他脑电图异常进行研究，有助于评估偏向性以及转诊和解释偏差。
回顾了1331例连续的成人脑电图报告，以检查癫痫样放电（EDs）和非癫痫样局灶性慢波。记录慢波或EDs出现的部位、解读脑电图的医生，以及患者是正在接受长期监测还是常规脑电图检查。对结果进行统计学分析。
局灶性慢波呈对称出现；EDs更倾向于出现在左侧半球（p < 0.01）。
在成年人中，左侧半球可能更容易出现癫痫样异常，但对于导致慢波的非特异性病理生理过程并非如此。这些发现表明，潜在的解释偏差并不会影响EDs在左侧半球的偏向性，相反可能暗示存在生物学病因。
