左侧大脑半球对匹鲁卡品诱导的大鼠癫痫样放电占优势。

Left hemisphere predominance of pilocarpine-induced rat epileptiform discharges.

机构信息

Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

出版信息

J Neuroeng Rehabil. 2009 Nov 30;6:42. doi: 10.1186/1743-0003-6-42.

DOI:10.1186/1743-0003-6-42

PMID:19948024

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2794280/

Abstract

BACKGROUND

The left cerebral hemisphere predominance in human focal epilepsy has been observed in a few studies, however, there is no related systematic study in epileptic animal on hemisphere predominance. The main goal of this paper is to observe if the epileptiform discharges (EDs) of Pilocarpine-induced epileptic rats could present difference between left hemisphere and right hemisphere or not.

METHODS

The electrocorticogram (ECoG) and electrohippocampogram (EHG) from Pilocarpine-induced epileptic rats were recorded and analyzed using Synchronization likelihood (SL) in order to determine the synchronization relation between different brain regions, then visual check and cross-correlation analysis were adopted to evaluate if the EDs were originated more frequently from the left hemisphere than the right hemisphere.

RESULTS

The data show that the synchronization between left-EHG and right-EHG, left-ECoG and left-EHG, right-ECoG and right-EHG, left-ECoG and right-ECoG, are significantly strengthened after the brain functional state transforms from non-epileptiform discharges to continuous-epileptiform discharges(p < 0.05). When the state transforms from continuous EDs to periodic EDs, the synchronization is significantly weakened between left-ECoG and left-EHG, left-EHG and right-EHG (p < 0.05). Visual check and the time delay (tau) based cross-correlation analysis finds that 10 out of 13 EDs have a left predominance (77%) and 3 out of 13 EDs are right predominance (23%).

CONCLUSION

The results suggest that the left hemisphere may be more prone to EDs in the Pilocarpine-induced rat epilepsy model and implicate that the left hemisphere might play an important role in epilepsy states transition.

摘要

背景

在少数研究中观察到人类局灶性癫痫中左大脑半球优势，但在癫痫动物中没有相关的系统研究。本文的主要目的是观察匹罗卡品诱导癫痫大鼠的癫痫样放电（EDs）是否在左半球和右半球之间存在差异。

方法

记录匹罗卡品诱导癫痫大鼠的皮质电图（ECoG）和海马电图（EHG），并使用同步似然度（SL）进行分析，以确定不同脑区之间的同步关系，然后进行视觉检查和互相关分析，以评估 ED 是否更频繁地源自左半球而不是右半球。

结果

数据显示，当脑功能状态从非癫痫样放电转变为连续癫痫样放电时，左-EHG 和右-EHG、左-ECoG 和左-EHG、右-ECoG 和右-EHG、左-ECoG 和右-ECoG 之间的同步性显著增强（p < 0.05）。当状态从连续 ED 转变为周期性 ED 时，左-ECoG 和左-EHG 之间以及左-EHG 和右-EHG 之间的同步性显著减弱（p < 0.05）。视觉检查和基于时间延迟（tau）的互相关分析发现，13 个 ED 中有 10 个（77%）表现出左优势，3 个（23%）表现出右优势。