Lemke T L, Cramer M B
J Med Chem. 1976 Jan;19(1):122-6. doi: 10.1021/jm00223a021.
A series of 2-substituted quinolizidines was synthesized and tested for their effects on motor activity in mice. In the 2-aryl-2-hydroxyquinolizidines (5 and 6) a difference was noted in potency between the axial and equatorial aryl analogs. A significant difference in activity was also found between the epimeric 2-(4-fluorobenzoyl) quinolizidines (10c and 11c).
合成了一系列2-取代喹嗪烷，并测试了它们对小鼠运动活性的影响。在2-芳基-2-羟基喹嗪烷（5和6）中，轴向和赤道芳基类似物之间的效价存在差异。在差向异构的2-(4-氟苯甲酰基)喹嗪烷（10c和11c）之间也发现了显著的活性差异。
