2,3-二羟基苯乙醇胺作为一种肾上腺素能剂。
2,3-Dihydroxyphenethanolamine as an adrenergic agent.
作者信息
Bartholow R B, Walaszek E J
出版信息
J Med Chem. 1976 Jan;19(1):189-90. doi: 10.1021/jm00223a039.
PMID:1246044
Abstract
In an attempt to further define the role of the m-hydroxy group in adrenergic agents, 2,3-dihydroxyphenethanolamine hydrobromide and N-isopropyl-2,3-dihydroxyphenethanolamine hydrobromide were prepared. These agents are less active than norepinephrine in alpha- and beta-adrenergic in vitro tests. The synthesis and conclusions from the tests are discussed.
摘要
为了进一步确定间羟基在肾上腺素能药物中的作用，制备了氢溴酸2,3 - 二羟基苯乙醇胺和氢溴酸N - 异丙基 - 2,3 - 二羟基苯乙醇胺。在体外α和β肾上腺素能测试中，这些药物的活性低于去甲肾上腺素。文中讨论了合成方法及测试结论。
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