Bartholow R B, Walaszek E J
J Med Chem. 1976 Jan;19(1):189-90. doi: 10.1021/jm00223a039.
In an attempt to further define the role of the m-hydroxy group in adrenergic agents, 2,3-dihydroxyphenethanolamine hydrobromide and N-isopropyl-2,3-dihydroxyphenethanolamine hydrobromide were prepared. These agents are less active than norepinephrine in alpha- and beta-adrenergic in vitro tests. The synthesis and conclusions from the tests are discussed.
为了进一步确定间羟基在肾上腺素能药物中的作用，制备了氢溴酸2,3 - 二羟基苯乙醇胺和氢溴酸N - 异丙基 - 2,3 - 二羟基苯乙醇胺。在体外α和β肾上腺素能测试中，这些药物的活性低于去甲肾上腺素。文中讨论了合成方法及测试结论。
