Drago J R, Rohner T J, Sanford E J, Engle J, Schoolwerth A
J Urol. 1976 Jan;115(1):105-7. doi: 10.1016/s0022-5347(17)59083-7.
Acute allergic interstitial nephritis is manifested clinically by rash, fever, eosinophilia, hematuria, oliguria and azotemia. Histologically a monocytic inflammatory process in the renal interstitium is seen. The clinical course of a patient after excessive sodium cephalothin administration suggested allergic interstitial nephritis and implicates this drug as an etiologic agent.
急性过敏性间质性肾炎的临床症状为皮疹、发热、嗜酸性粒细胞增多、血尿、少尿和氮质血症。组织学检查可见肾间质有单核细胞炎性过程。一名患者在过量使用头孢噻吩钠后的临床病程提示为过敏性间质性肾炎,表明该药物是病因。