Heinzel Amy S, Grotzke Jeff E, Lines Rebecca A, Lewinsohn Deborah A, McNabb Andria L, Streblow Daniel N, Braud Veronique M, Grieser Heather J, Belisle John T, Lewinsohn David M
Division of Pulmonary & Critical Care Medicine, Portland VA Medical Center, Oregon Health Sciences University, Portland, OR 97201, USA.
J Exp Med. 2002 Dec 2;196(11):1473-81. doi: 10.1084/jem.20020609.
Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.
先前在小鼠和人类中的研究表明，CD8 + T细胞在宿主抗结核分枝杆菌防御中起重要作用。最近，我们描述了既不受HLA - A、B或C限制，也不受1类CD1限制的人类结核分枝杆菌特异性CD8 +细胞，并发现这些细胞构成了潜伏感染个体中主要的CD8 + T细胞应答。在本报告中，使用了三种独立方法来证明这些细胞在单态性HLA - E分子背景下识别结核分枝杆菌衍生抗原的能力。这是首次证明HLA - E呈递病原体衍生抗原的能力。对HLA - E特异性应答的进一步定义可能有助于开发有效的抗结核疫苗。
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