免疫球蛋白跨极化上皮细胞的转运。

Immunoglobulin transport across polarized epithelial cells.

作者信息

Rojas Raul, Apodaca Gerard

机构信息

Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

出版信息

Nat Rev Mol Cell Biol. 2002 Dec;3(12):944-55. doi: 10.1038/nrm972.

DOI:10.1038/nrm972

PMID:12461560

Abstract

IgA, IgG and IgM are transported across epithelial cells in a receptor-mediated process known as transcytosis. In addition to neutralizing pathogens in the lumen of the gastrointestinal, respiratory and urogenital tracts, these antibody-receptor complexes are now known to mediate intracellular neutralization of pathogens and might also be important in immune activation and tolerance. Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways.

摘要

IgA、IgG和IgM通过一种称为转胞吞作用的受体介导过程穿过上皮细胞。除了中和胃肠道、呼吸道和泌尿生殖道管腔中的病原体外，现在已知这些抗体-受体复合物还介导细胞内病原体的中和作用，并且在免疫激活和耐受中可能也很重要。最近关于抗体-受体复合物的细胞内运输途径以及抗体刺激的受体介导转胞吞作用的研究，正在为内吞途径的性质和调控提供新的见解。