How do microtubules guide migrating cells?
作者信息
Small J Victor, Geiger Benjamin, Kaverina Irina, Bershadsky Alexander
出版信息
Nat Rev Mol Cell Biol. 2002 Dec;3(12):957-64. doi: 10.1038/nrm971.
DOI:10.1038/nrm971
PMID:12461561
Abstract
Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.
摘要
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