Shaffer A L, Rosenwald Andreas, Staudt Louis M
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nat Rev Immunol. 2002 Dec;2(12):920-32. doi: 10.1038/nri953.
When the regulation of B-cell differentiation and activation is disrupted, lymphomas and leukaemias can occur. The processes that normally create immunoglobulin diversity might be misdirected, resulting in oncogenic chromosomal translocations that block differentiation, prevent apoptosis and/or promote proliferation. Prolonged or unregulated antigenic stimulation might contribute further to the development and progression of some malignancies. Lymphoid malignancies often resemble normal stages of B-cell differentiation, as shown by molecular techniques such as gene-expression profiling. The similarities and differences between malignant and normal B cells indicate strategies for the treatment of these cancers.
当B细胞分化和激活的调节被破坏时，可能会发生淋巴瘤和白血病。正常情况下产生免疫球蛋白多样性的过程可能会被误导，导致致癌性染色体易位，从而阻碍分化、阻止细胞凋亡和/或促进增殖。长期或不受调控的抗原刺激可能会进一步促进某些恶性肿瘤的发生和发展。通过基因表达谱分析等分子技术表明，淋巴系统恶性肿瘤通常类似于B细胞分化的正常阶段。恶性B细胞与正常B细胞之间的异同表明了这些癌症的治疗策略。
