Rudin C M, Thompson C B
Gwen Knapp Center for Lupus and Immunology Research, the Department of Medicine, Howard Hughes Medical Institute, University of Chicago, IL 60637, USA.
Semin Oncol. 1998 Aug;25(4):435-46.
Approximately 85% of all non-Hodgkin's lymphomas arise from cells of the B lineage. Sequential stages of B-cell development have been defined by molecular markers, and these markers can be used to reclassify lymphoid malignancies as representing maturational arrest and immortalization at specific points in B-cell ontogeny. Several of the factors controlling the ordered rearrangement and expression of the immunoglobulin (Ig) genes have been identified. Signals generated by intermediates in Ig gene rearrangement, as well as by the complete Ig molecule, have been found to be critical in guiding early B-cell development. The processes of peripheral B-cell activation, antigenic affinity maturation, and terminal B-cell differentiation are also highly regulated. The molecular mechanisms responsible for both promoting and attenuating B-cell (humoral) immune responses have been increasingly well defined. This review summarizes some aspects of the current understanding of normal B-cell development, maturation, activation, and death, focusing on the factors implicated in regulating progression through these stages.
大约85%的非霍奇金淋巴瘤起源于B淋巴细胞系细胞。B细胞发育的连续阶段已通过分子标志物得以界定，这些标志物可用于将淋巴恶性肿瘤重新分类，以表明其在B细胞个体发生的特定阶段出现成熟停滞和永生。已经确定了几个控制免疫球蛋白（Ig）基因有序重排和表达的因素。已发现由Ig基因重排中间体以及完整Ig分子产生的信号对于指导早期B细胞发育至关重要。外周B细胞激活、抗原亲和力成熟和终末B细胞分化过程也受到高度调控。促进和减弱B细胞（体液）免疫反应的分子机制已越来越明确。本综述总结了目前对正常B细胞发育、成熟、激活和死亡的一些理解，重点关注与调控这些阶段进展相关的因素。
