Moretta Alessandro
Dipartimento di Medicina Sperimentale, Sezione di Istologia, and Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, 16132 Genova, Italy.
Nat Rev Immunol. 2002 Dec;2(12):957-64. doi: 10.1038/nri956.
Natural killer (NK) cells and dendritic cells (DCs) are two types of specialized cell of the innate immune system, the reciprocal interaction of which results in a potent, activating cross-talk. For example, DCs can prime resting NK cells, which, in turn, after activation, might induce DC maturation. However, NK cells negatively regulate the function of DCs also by killing immature DCs in peripheral tissues. Moreover, a subset of NK cells, after migration to secondary lymphoid tissues, might have a role in the editing of mature DCs based on the selective killing of mature DCs that do not express optimal surface densities of MHC class I molecules. So, cognate interactions between NK cells and DCs provide a coordinated mechanism that is involved not only in the regulation of innate immunity, but also in the promotion of appropriate downstream adaptive responses for defence against pathogens.
自然杀伤（NK）细胞和树突状细胞（DC）是先天性免疫系统中的两种特殊细胞类型，它们之间的相互作用会产生强大的激活串扰。例如，DC可以激活静息的NK细胞，而激活后的NK细胞反过来可能会诱导DC成熟。然而，NK细胞也会通过杀伤外周组织中的未成熟DC来负向调节DC的功能。此外，一部分NK细胞迁移至次级淋巴组织后，可能会基于对不表达最佳表面密度MHC I类分子的成熟DC的选择性杀伤，参与成熟DC的编辑过程。因此，NK细胞与DC之间的同源相互作用提供了一种协调机制，不仅参与先天性免疫的调节，还促进针对病原体防御的适当下游适应性反应。
