Moretta Alessandro, Marcenaro Emanuela, Sivori Simona, Della Chiesa Mariella, Vitale Massimo, Moretta Lorenzo
Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132 Italy.
Trends Immunol. 2005 Dec;26(12):668-75. doi: 10.1016/j.it.2005.09.008. Epub 2005 Sep 28.
The crosstalk between natural killer (NK) cells and myeloid dendritic cells (DCs) results in NK-cell activation and DC maturation. Activated NK cells acquire the ability to kill DCs that have failed to undergo complete maturation ('DC editing'). Recent studies have revealed that this crosstalk can be promoted by pathogen-derived products that activate different innate immune cell types directly and simultaneously through their Toll-like receptors (TLRs). These cells include NK cells and DCs, as well as plasmacytoid DCs (PDCs) and mast cells. This crosstalk can have a great impact on the quality and strength of the subsequent adaptive immune response. Thus, NK cells have an important role in the defense against pathogens, acting as regulatory cells as well as effector cells.
自然杀伤（NK）细胞与髓样树突状细胞（DC）之间的相互作用导致NK细胞活化和DC成熟。活化的NK细胞获得了杀死未能完全成熟的DC的能力（“DC编辑”）。最近的研究表明，病原体衍生产物可通过其Toll样受体（TLR）直接并同时激活不同的天然免疫细胞类型，从而促进这种相互作用。这些细胞包括NK细胞和DC，以及浆细胞样DC（pDC）和肥大细胞。这种相互作用可对随后的适应性免疫反应的质量和强度产生重大影响。因此，NK细胞在抵御病原体方面发挥着重要作用，既是调节细胞又是效应细胞。
