Nezhinskaia G I, Sapronov N S
Patol Fiziol Eksp Ter. 2002 Jul-Sep(3):22-5.
The authors discuss mechanisms of action of immunocorrectors the targets of which are various populations of antigen-presenting lymphoid cells and approaches to application of modulators with different mechanisms of action in disease. To assess a long-term effect of the drug which produces an oscillatory effect (activation/suppression) on T and B cell activity, competitive relations between T and B cells should be tested and taken into account. Common practice of immunocorrection on the basis of T cell activity without consideration of the functional state of other lymphoid sets, especially B cells, deteriorates efficacy of immunocorrection. It is necessary to know the time of T- and B-cell activation and suppression to schedule combined use of drugs with different mechanisms of action.
作者们讨论了免疫校正剂的作用机制，其作用靶点为各种抗原呈递淋巴细胞群体，还讨论了具有不同作用机制的调节剂在疾病中的应用方法。为评估对T和B细胞活性产生振荡效应（激活/抑制）的药物的长期效果，应检测并考虑T细胞和B细胞之间的竞争关系。在不考虑其他淋巴细胞群体尤其是B细胞功能状态的情况下，基于T细胞活性进行免疫校正的常规做法会降低免疫校正的效果。有必要了解T细胞和B细胞激活与抑制的时间，以便安排具有不同作用机制的药物联合使用。
