[Assessment of the rhythm of lymphocyte stimulation and suppression as a criterion of prognosis of the effects of immunomodulatory drugs].

The authors discuss mechanisms of action of immunocorrectors the targets of which are various populations of antigen-presenting lymphoid cells and approaches to application of modulators with different mechanisms of action in disease. To assess a long-term effect of the drug which produces an oscillatory effect (activation/suppression) on T and B cell activity, competitive relations between T and B cells should be tested and taken into account. Common practice of immunocorrection on the basis of T cell activity without consideration of the functional state of other lymphoid sets, especially B cells, deteriorates efficacy of immunocorrection. It is necessary to know the time of T- and B-cell activation and suppression to schedule combined use of drugs with different mechanisms of action.