Kessel Line, Kalinin Stanislav, Nagaraj Ram H, Larsen Michael, Johansson Lennart B A
Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Photochem Photobiol. 2002 Nov;76(5):549-54. doi: 10.1562/0031-8655(2002)076<0549:trassf>2.0.co;2.
The intrinsic fluorescence from the human lens on excitation in the UV region, referred to as blue lens autofluorescence, increases with age or in the presence of diabetes. The present study reveals that the relative contribution of compounds responsible for the blue autofluorescence appears to be a constant with age. Three potential candidates for the blue fluorescence were also studied with respect to fluorescence spectroscopic properties. These were argpyrimidine and pentosidine, both advanced glycation end products, and 3-hydroxykynurenine (3-OH-kynurenine), a photooxidative derivative of tryptophan. It was shown that the spectral properties of argpyrimidine and pentosidine are compatible with the observed blue fluorescence of the human lens, whereas the fluorescence from 3-OH-kynurenine is negligible.
人晶状体在紫外区域激发时的固有荧光，即所谓的蓝色晶状体自发荧光，会随着年龄增长或在糖尿病存在的情况下增加。本研究表明，导致蓝色自发荧光的化合物的相对贡献似乎随年龄增长保持恒定。还针对荧光光谱特性研究了三种蓝色荧光的潜在候选物质。它们是精氨嘧啶和戊糖苷，均为晚期糖基化终产物，以及3-羟基犬尿氨酸（3-OH-犬尿氨酸），一种色氨酸的光氧化衍生物。结果表明，精氨嘧啶和戊糖苷的光谱特性与观察到的人晶状体蓝色荧光相符，而3-OH-犬尿氨酸的荧光可忽略不计。
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