Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Department of Epidemic Disease Research, Institute of Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.
Mol Neurobiol. 2018 Sep;55(9):7438-7452. doi: 10.1007/s12035-018-0935-x. Epub 2018 Feb 8.
Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson's diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.
晚期糖基化终产物（AGEs）与包括阿尔茨海默病和帕金森病在内的几种中枢神经系统（CNS）疾病有关。面对 AGE 的威胁，我们试图研究氧化锌纳米粒子（ZnONP）在抑制 AGE 形成中的作用。合成的 ZnONPs 用于研究其对 AGE 形成的抑制作用。通过生物物理免疫和生化技术确定 ZnONPs 对 AGE 形成的抑制作用。结果表明，ZnONP 是一种有潜力的抗糖化剂，可抑制 AGE 的形成，并保护蛋白质结构免受变化。因此，我们的研究结果表明，ZnONPs 可能可用于治疗 CNS 相关并发症中 AGE 的作用。
