Robert M F, Neff R K, Hubbell J P, Taeusch H W, Avery M E
N Engl J Med. 1976 Feb 12;294(7):357-60. doi: 10.1056/NEJM197602122940702.
Perinatal data on 805 infants of diabetic mothers and 10,152 infants of nondiabetic mothers were examined for a relation between maternal diabetes and respiratory-distress syndrome of the newborn. The syndrome occurred in 23.4 per cent of the diabetic vs. 1.3 per cent of the nondiabetic group. The risk of the syndrome in an infant of a diabetic mother was 23.7 times greater than that for an infant of a nondiabetic mother (P less than 0.00001). Further analysis to control for features associated with diabetes but also in themselves risk factors, such as gestational age and route of delivery, showed that respiratory-distress syndrome in infants of diabetic mothers was 5.6 times as likely to develop as in infants of nondiabetic mothers (P less than 0.00001). Thus, maternal diabetes mellitus per se predisposes to newborn respiratory-distress syndrome.
对805例糖尿病母亲的婴儿和10152例非糖尿病母亲的婴儿的围产期数据进行了检查，以研究母亲糖尿病与新生儿呼吸窘迫综合征之间的关系。该综合征在糖尿病组中的发生率为23.4%，而非糖尿病组为1.3%。糖尿病母亲的婴儿患该综合征的风险比非糖尿病母亲的婴儿高23.7倍（P小于0.00001）。进一步分析以控制与糖尿病相关但本身也是危险因素的特征，如孕周和分娩方式，结果显示糖尿病母亲的婴儿发生呼吸窘迫综合征的可能性是非糖尿病母亲婴儿的5.6倍（P小于0.00001）。因此，母亲糖尿病本身易导致新生儿呼吸窘迫综合征。
