Williams D L
Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES.
J Small Anim Pract. 2002 Nov;43(11):478-81. doi: 10.1111/j.1748-5827.2002.tb00017.x.
Twenty eyes of 10 dogs with keratoconjunctivitis sicca (KCS) were treated by occlusion of the ventral nasolacrimal punctum with a silicone punctal plug in order to increase the volume of the remaining tear lake. Punctal size was measured using a commercially available punctal gauge and the appropriate sized plug was inserted under local anaesthesia. Seven dogs showed an increase in Schirmer tear test I (STT) value. STT values immediately prior to plug placement were 2.3 +/- 1.7 mm/minute. STT values with punctal occlusion were 6.1 +/- 4.1 mm/minute, giving a mean increase of 3.8 +/- 2.7 mm/minute (P<0.001). In 14 eyes of eight dogs, the increase in STT values was accompanied by a clinical improvement in the appearance of the ocular surface. In the three dogs with no increase in STT values, the use of punctal plugs reduced the frequency of artificial tear replacement therapy required to maintain a healthy ocular surface. These results show that use of punctal plugs in dogs with KCS may be appropriate where other lacrimomimetic medications have been unsuccessful.
为增加剩余泪湖的容量，对10只患有干眼症（KCS）的犬的20只眼睛采用硅胶泪点塞阻塞鼻泪管下泪点进行治疗。使用市售的泪点测量仪测量泪点大小，并在局部麻醉下插入合适尺寸的泪点塞。7只犬的Schirmer泪液试验I（STT）值增加。放置泪点塞前的STT值为2.3±1.7毫米/分钟。泪点阻塞后的STT值为6.1±4.1毫米/分钟，平均增加3.8±2.7毫米/分钟（P<0.001）。在8只犬的14只眼睛中，STT值的增加伴随着眼表外观的临床改善。在3只STT值未增加的犬中，使用泪点塞减少了维持健康眼表所需的人工泪液替代疗法的频率。这些结果表明，在其他拟泪药物治疗失败的情况下，对患有KCS的犬使用泪点塞可能是合适的。
