Tallia Alfred F, Cardone Dennis A
Department of Family Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, USA.
J Am Board Fam Pract. 2002 Nov-Dec;15(6):481-4.
Although dietary supplements are in widespread use, and some have been endorsed by the medical community and complementary and alternative practitioners, not much is known about their potential side effects or drug interactions.
A case of asthma exacerbated by the use of a glucosamine-chondroitin supplement for osteoarthritis pain is described. The literature was searched from 1980 to 2002 using the terms "glucosamine," "chondroitin sulfate," "alternative medicine," and "dietary supplements," combined with "asthma."
The biological link between both chondroitin and glucosamine and secretions from the respiratory tree of persons with asthma lends biologic plausibility to the hypothesis that the patient's asthmatic episode was related to the dietary substance. Physicians would be wise to question their patients about use of dietary supplements as self-medication and consider the possibility of such supplements causing exacerbations of underlying conditions.
尽管膳食补充剂被广泛使用，并且一些已得到医学界以及补充与替代医学从业者的认可，但对于它们潜在的副作用或药物相互作用却知之甚少。
描述了一例因使用氨基葡萄糖 - 软骨素补充剂治疗骨关节炎疼痛而加重哮喘的病例。使用“氨基葡萄糖”“硫酸软骨素”“替代医学”“膳食补充剂”以及“哮喘”等关键词，检索了1980年至2002年的文献。
软骨素和氨基葡萄糖与哮喘患者呼吸道分泌物之间的生物学联系，使得患者哮喘发作与该膳食物质有关这一假说具有生物学合理性。医生明智的做法是询问患者使用膳食补充剂进行自我治疗的情况，并考虑此类补充剂导致基础疾病加重的可能性。
