Turpie Alexander G G
McMaster University Hamilton Health Sciences Corporation-General Site, Hamilton, Ontario, Canada.
Am J Orthop (Belle Mead NJ). 2002 Nov;31(11 Suppl):11-5.
Many clinicians recommend long-term, postoperative thromboprophylaxis for patients who undergo major hip or knee replacement or hip fracture surgery. However, special care must be taken when administering pharmacoprophylaxis to such patients, as they commonly exhibit characteristics that are different from those of the general population and can affect their responses to certain drugs. Among the currently available thromboprophylactic agents are warfarin, the heparins, and the recently introduced selective factor Xa inhibitor, fondaparinux. One feature of fondaparinux is that it can be administered safely and efficaciously in a wide variety of patient populations, without the need for dosage modification.
许多临床医生建议，对于接受髋关节或膝关节置换术或髋部骨折手术的患者进行长期术后血栓预防。然而，对此类患者进行药物预防时必须格外小心，因为他们通常表现出与普通人群不同的特征，并且这些特征可能会影响他们对某些药物的反应。目前可用的血栓预防药物包括华法林、肝素，以及最近引入的选择性Xa因子抑制剂磺达肝癸钠。磺达肝癸钠的一个特点是，它可以在各种患者群体中安全有效地给药，无需调整剂量。
