疫苗与黑色素瘤

Vaccines and melanoma.

作者信息

Nestle F O

机构信息

Department of Dermatology, University of Zürich Hospital, Germany.

出版信息

Clin Exp Dermatol. 2002 Oct;27(7):597-601. doi: 10.1046/j.1365-2230.2002.01152.x.

DOI:10.1046/j.1365-2230.2002.01152.x

PMID:12464156

Abstract

Melanoma is one of the prototypic immunogenic tumors. Various immunotherapeutic approaches for melanoma have been developed in the past decades. Recent scientific progress includes the discovery of defined melanoma antigens, new tools for monitoring of an anti-cancer immune response and application of novel adjuvants for amplification of the immune response such as dendritic cells. These and other advances in the field of melanoma vaccines will be discussed.

摘要

黑色素瘤是典型的免疫原性肿瘤之一。在过去几十年中，已经开发出了多种针对黑色素瘤的免疫治疗方法。最近的科学进展包括确定黑色素瘤抗原、监测抗癌免疫反应的新工具以及应用新型佐剂（如树突状细胞）来增强免疫反应。本文将讨论黑色素瘤疫苗领域的这些以及其他进展。