Kupper Thomas S, Fuhlbrigge Robert C
Department of Dermatology, Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Nat Rev Immunol. 2004 Mar;4(3):211-22. doi: 10.1038/nri1310.
The skin, as the primary interface between the body and the environment, provides the first line of defence against a broad array of microbial pathogens and trauma. In addition to its properties as a physical barrier, the skin has many active defence mechanisms. In this review, we discuss the interaction between the innate and adaptive immune systems in the skin as a model for immune function at epithelial-cell interfaces with the environment. How these mechanisms account for the robust nature of cutaneous immune surveillance and how their dysregulation drives the pathogenesis of inflammatory skin disorders and skin-based tumours are the subjects of this review.
皮肤作为身体与环境之间的主要界面，为抵御多种微生物病原体和创伤提供了第一道防线。除了作为物理屏障的特性外，皮肤还有许多主动防御机制。在本综述中，我们将探讨皮肤中先天性和适应性免疫系统之间的相互作用，以此作为上皮细胞与环境界面免疫功能的模型。这些机制如何解释皮肤免疫监视的强大本质，以及它们的失调如何驱动炎症性皮肤病和皮肤肿瘤的发病机制，是本综述的主题。
