Georgiou George
Department of Chemical Engineering, Institute for Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA.
Cell. 2002 Nov 27;111(5):607-10. doi: 10.1016/s0092-8674(02)01165-0.
Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways.
氧化还原敏感的转录因子，如大肠杆菌的OxyR和酿酒酵母的Yap1，通过反应性蛋白质硫醇的翻译后修饰引起的构象变化而被激活。最近的研究为不同的引起氧化还原应激的因子如何通过不同且特定的途径介导转录激活提供了新的见解。
