Berent S, Giordani B, Gilman S, Trask C L, Little R J A, Johanns J R, Junck L, Kluin K J, Heumann M, Koeppe R A
Division of Neuropsychology, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109-0840, USA.
Brain Cogn. 2002 Nov;50(2):194-206. doi: 10.1016/s0278-2626(02)00503-1.
Although neuropsychological symptoms are associated with multiple system atrophy (MSA), sporadic olivopontocerebellar atrophy (sOPCA), and dominantly inherited olivopontocerebellar atrophy (dOPCA), the differences between these groups have not been explored. We compared 28 MSA patients on psychiatric rating scales and neuropsychological measures to 67 sOPCA patients, 42 dOPCA patients, and 30 normal controls. Patients with dOPCA, sOPCA, and MSA all exhibited significant deficits on motor-related tasks, as well as relatively mild deficits in cognitive functioning. Patients with MSA had greater neuropsychological dysfunction, particularly in memory and other "higher order" cognitive processes, than patients with either sOPCA or dOPCA.
尽管神经心理学症状与多系统萎缩（MSA）、散发性橄榄脑桥小脑萎缩（sOPCA）和显性遗传性橄榄脑桥小脑萎缩（dOPCA）相关，但尚未对这些组之间的差异进行探索。我们将28例MSA患者在精神评定量表和神经心理学测量方面与67例sOPCA患者、42例dOPCA患者和30名正常对照进行了比较。dOPCA、sOPCA和MSA患者在与运动相关的任务上均表现出显著缺陷，以及在认知功能方面相对较轻的缺陷。与sOPCA或dOPCA患者相比，MSA患者有更严重的神经心理学功能障碍，尤其是在记忆和其他“高级”认知过程方面。
