Wilson Iain B H
Institut für Chemie der Universität für Bodenkultur, Muthgasse 18, A-1190 Vienna, Austria.
Curr Opin Struct Biol. 2002 Oct;12(5):569-77. doi: 10.1016/s0959-440x(02)00367-6.
N-glycosylation is the most conserved form of protein glycosylation in eukaryotes, but the modifications of N-linked oligosaccharides in plants and invertebrates often differ greatly from those in vertebrates and sometimes result in immunogenic structures. By contrast, O-linked glycans tend to be a wide and disparate group of modifications. Whereas the forms of O-linked glycans in plants are unlike those in animals, studies on invertebrate O-glycosylation often yield information relevant to mammalian systems.
N-糖基化是真核生物中蛋白质糖基化最保守的形式,但植物和无脊椎动物中N-连接寡糖的修饰往往与脊椎动物有很大差异,有时会产生免疫原性结构。相比之下,O-连接聚糖往往是一组广泛且不同的修饰。虽然植物中O-连接聚糖的形式与动物不同,但对无脊椎动物O-糖基化的研究常常能产生与哺乳动物系统相关的信息。