Fukuoka Yuko, Komori Hiromichi, Kawabata Shigenori, Ohkubo Harunobu, Shinomiya Kenichi, Terasaki Omi
Section of Orthopedic Spinal Surgery, Department of Frontier Surgical Therapeutics, Division of Advanced Therapeutical Sciences, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan.
Clin Neurophysiol. 2002 Dec;113(12):1985-92. doi: 10.1016/s1388-2457(02)00345-0.
For the clinical application of neuromagnetic recordings in neural conduction block, the patterns of magnetic fields in the region should be clarified. Using an experimental in vitro model, the spatiotemporal course of the neuromagnetic fields at the site of complete conduction block was examined. Additionally, the magnetic compound action fields (CAFs) and electric compound action potentials (CAPs) were compared and correlated.
In a chamber containing Ringer's solution, 10 isolated sciatic nerves of rabbits were electrically stimulated. Both evoked CAPs and CAFs were measured before and after the ligation of the nerve. The sequential positions of the current dipoles and the location of the conduction block were estimated by the least-squares search.
The magnetic contour maps of the CAFs showed a characteristic quadrupolar pattern propagating along the nerve. The peak of the leading magnetic field ceased and disappeared at the position of the nerve ligation, while the trailing magnetic field became attenuated before reaching that position. The positions of the conduction blocks were localized by magnetic recordings within a difference of 2mm.
The neuromagnetic recordings could visualize the change of the magnetic fields at the site of the complete conduction block and closely localize that position.
The neural conduction block was visualized and localized by neuromagnetic recordings.
为了将神经磁记录应用于神经传导阻滞的临床，需要明确该区域的磁场模式。利用体外实验模型，研究了完全传导阻滞部位神经磁场的时空过程。此外，还对磁复合动作场（CAF）和电复合动作电位（CAP）进行了比较和相关性分析。
在含有林格氏液的腔室内，对10条兔离体坐骨神经进行电刺激。在神经结扎前后分别测量诱发的CAP和CAF。通过最小二乘法搜索估计电流偶极子的顺序位置和传导阻滞的位置。
CAF的磁轮廓图显示出沿神经传播的特征性四极模式。领先磁场的峰值在神经结扎位置停止并消失，而后继磁场在到达该位置之前减弱。通过磁记录将传导阻滞的位置定位在2mm的误差范围内。
神经磁记录可以可视化完全传导阻滞部位的磁场变化，并精确地定位该位置。
通过神经磁记录实现了神经传导阻滞的可视化和定位。
