Leyton Marco, Boileau Isabelle, Benkelfat Chawki, Diksic Mirko, Baker Glen, Dagher Alain
Department of Psychiatry, McGill University, Montréal, Québec, Canada.
Neuropsychopharmacology. 2002 Dec;27(6):1027-35. doi: 10.1016/S0893-133X(02)00366-4.
Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.). PET data were analyzed using: (1) brain parametric maps to statistically generate regions of significant change; and (2) a priori identified regions of interest (ROI) manually drawn on each individual's co-registered magnetic resonance (MR) images. Compared with placebo, d-amphetamine decreased [11C]raclopride binding potential (BP) with significant effects in ventral but not dorsal striatum. Change in BP in the statistically generated cluster correlated with self-reported drug-induced 'drug wanting' (r = 0.83, p =.01) and the personality trait of Novelty Seeking-Exploratory Excitability (r = 0.79, p =.02). The same associations were seen in the manually drawn ROI in ventral striatum but not in dorsal putamen or caudate. Changes in extracellular dopamine (DA) did not correlate with mood. Mesolimbic DA might mediate interest in obtaining reward rather than reward, per se. Individual differences in amphetamine-induced DA release might be related to predispositions to drug and novelty seeking.
八名健康男性接受了两次正电子发射断层扫描（PET）[11C]雷氯必利扫描，一次在服用安慰剂后进行，第二次在服用右旋苯丙胺（0.30毫克/千克，口服）后进行。PET数据采用以下方法进行分析：（1）脑参数图以统计学方式生成显著变化区域；（2）在每个个体的配准磁共振（MR）图像上手动绘制预先确定的感兴趣区域（ROI）。与安慰剂相比，右旋苯丙胺降低了[11C]雷氯必利结合潜能（BP），在腹侧纹状体有显著影响，而在背侧纹状体则无。统计学生成的簇中BP的变化与自我报告的药物诱导的“渴望药物”（r = 0.83，p = 0.01）以及寻求新奇 - 探索性兴奋性的人格特质（r = 0.79，p = 0.02）相关。在腹侧纹状体手动绘制的ROI中也观察到了相同的关联，但在背侧壳核或尾状核中未观察到。细胞外多巴胺（DA）的变化与情绪无关。中脑边缘多巴胺可能介导对获得奖励的兴趣，而非奖励本身。苯丙胺诱导的DA释放的个体差异可能与药物易感性和寻求新奇有关。
