Lewy J E
Pediatr Res. 1976 Jan;10(1):30-4. doi: 10.1203/00006450-197601000-00006.
The relationship between glomerular filtration rate and proximal tubular fluid reabsorption was evaluated in control rats and in rats 96 and 144 hr after the injection of an aminonucleoside of puromycin. Urine volume and sodium excretion were decreased in the rats injected with aminonucleoside. Proteinuria increased progressively. Total kidney glomerular filtration rate (GFR) was diminished less than surface nephron GFR at 96 hr and greater than single nephron GFR at 144 hr after injection when a large proportion of nephrons are nonfunctional. Clearance of p-aminohippurate was unchanged initially and depressed subsequently after aminonucleoside injection. Absolute reabsorption to the end of the proximal convolution was unaltered despite a decrease in total kidney filtration fraction. This decrease in GFR coupled with unchanged absolute reabsorption and hence increased fractional proximal reabsorption leads to decreased delivery of sodium and fluid to the more distal portions of the nephron.
在对照大鼠以及注射嘌呤霉素氨基核苷后96小时和144小时的大鼠中，评估了肾小球滤过率与近端肾小管液重吸收之间的关系。注射嘌呤霉素氨基核苷的大鼠尿量和钠排泄减少。蛋白尿逐渐增加。注射后96小时，总肾肾小球滤过率（GFR）的降低小于表层肾单位GFR，而在144小时，当大部分肾单位无功能时，总肾肾小球滤过率大于单个肾单位GFR。对氨基马尿酸清除率在注射嘌呤霉素氨基核苷后最初未改变，随后降低。尽管总肾滤过分数降低，但近端曲管末端的绝对重吸收未改变。GFR的这种降低与绝对重吸收不变以及因此近端重吸收分数增加导致钠和液体向肾单位更远端部分的输送减少。
