Bekeredjian Raffi, Hansen Alexander, Filusch Arthur, Dubart Alain-Eric, Da Silva Kleber Gaspar Carvallho, Hardt Stefan S, Korosoglou Gregorius, Kuecherer Helmut F
University of Heidelberg, Germany.
J Am Soc Echocardiogr. 2002 Dec;15(12):1425-31. doi: 10.1067/mje.2002.128471.
The presence of cyclic intensity variation during real-time myocardial perfusion imaging (RTPI) has been controversially discussed. We investigated whether cyclic intensity variation is systematically found during RTPI and whether such variations are related to regional functional parameters.
Intraoperative RTPI were obtained in 12 pigs before, during, and after left descending coronary artery occlusion with 60 mL/h SonoVue infusion. Furthermore, RTPI was performed in 14 patients after slow bolus injection of 0.7 mL of Optison. Instantaneous regional systolic to diastolic (S/D) myocardial intensity ratios were calculated after high mechanical index bubble destruction. S/D ratios were correlated with A- and beta-values, and fractional area shortening.
Systematic cyclic S/D changes were present in both experimental settings showing significantly higher systolic values (animals, S/D 1.28 +/- 0.44; patients, S/D 1.25 +/- 0.7). Cyclic S/D variation was not related to fractional area shortening, or A- or beta-values (all r < 0.3, not significant).
Consistent cyclic changes in myocardial contrast intensity can be measured both in intraoperative animals and in patients, showing higher systolic values. S/D ratios are not related to regional functional parameters.
实时心肌灌注成像（RTPI）期间循环强度变化的存在一直存在争议。我们研究了在RTPI期间是否能系统地发现循环强度变化，以及这种变化是否与局部功能参数相关。
对12头猪在左冠状动脉前降支闭塞前、闭塞期间及闭塞后以60 mL/h的速度输注声诺维时进行术中RTPI检查。此外，对14例患者在缓慢推注0.7 mL欧乃影后进行RTPI检查。在高机械指数破坏气泡后计算瞬时局部心肌收缩期与舒张期（S/D）强度比。S/D比值与A值、β值及面积缩短分数相关。
在两种实验设置中均存在系统性的循环S/D变化，收缩期值显著更高（动物组，S/D 1.28±0.44；患者组，S/D 1.25±0.7）。循环S/D变化与面积缩短分数、A值或β值均无关（所有r<0.3，无显著性差异）。
在术中动物和患者中均可测量到心肌对比强度的一致性循环变化，收缩期值更高。S/D比值与局部功能参数无关。
