Asami Takeshi, Kokawa Atsushi, Sugimori Kazuya, Tomita Naohiko, Shirato Kazuhito, Morimoto Manabu, Saito Toshifumi, Tanaka Katsuaki, Imada Toshio
Gastroenterological Center, Yokohama City University Medical Center.
Gan To Kagaku Ryoho. 2002 Nov;29(11):1985-8.
A case of AFP-producing gastric cancer successfully treated with CPT-11 and cisplatin combined therapy is reported together with a review of the literature. A 52-year-old male was admitted with complaints of upper abdominal pain and body weight loss. Gastric cancer with multiple liver metastases was diagnosed based on endoscopy and computed tomography findings. The patient's serum AFP level was 697,100 ng/ml and a biopsy specimen showed AFP-positive tumor cells immunohistochemically. He was treated with a combination chemotherapy consisting of CPT-11 (70 mg/m2) on day 1 and 15, and cisplatin (80 mg/m2) on day 1, repeated every 4 weeks. The primary lesion of the stomach and the liver metastases were remarkably reduced, and the serum level of AFP decreased to 18 ng/ml after 5 cycles of this treatment. No severe side effects were seen during this treatment. This result suggests that combination chemotherapy consisting of CPT-11 and cisplatin may be effective and safe for patients with AFP-producing gastric cancer with multiple liver metastases.
报告了一例采用伊立替康和顺铂联合疗法成功治疗的产甲胎蛋白胃癌病例，并对相关文献进行了综述。一名52岁男性因上腹部疼痛和体重减轻入院。根据内镜检查和计算机断层扫描结果诊断为伴有多处肝转移的胃癌。患者血清甲胎蛋白水平为697,100 ng/ml，活检标本经免疫组化显示甲胎蛋白阳性肿瘤细胞。他接受了联合化疗，第1天和第15天使用伊立替康（70 mg/m²），第1天使用顺铂（80 mg/m²），每4周重复一次。胃的原发灶和肝转移灶明显缩小，经过5个周期的这种治疗后，血清甲胎蛋白水平降至18 ng/ml。治疗期间未观察到严重副作用。这一结果表明，伊立替康和顺铂组成的联合化疗可能对伴有多处肝转移的产甲胎蛋白胃癌患者有效且安全。
