Gonda T, Ishida H, Higuchi T, Hirukawa H, Nakajima H, Hojo I, Mishima Y
Dept. of Surgery, Niigata Prefectural Tokamachi Hospital.
Gan To Kagaku Ryoho. 1994 Aug;21(10):1659-63.
A case of AFP producing gastric cancer successfully treated with EAP therapy is reported with a review of the literature. A 56-year-old male was admitted complaining of epigastralgia and back pain. He was diagnosed as having a gastric cancer with multiple liver metastases by endoscopy and computed tomography. Serum AFP level was 2,791,000 ng/ml and biopsy specimen showed AFP-positive tumor cells by PAP (peroxidase-antiperoxidase) method in hepatoid structure. Preoperative combination chemotherapy with etoposide, adriamycin and cisplatin resulted in a remarkable decrease in serum AFP level. Subtotal gastrectomy (R3) with hepatic artery cannulation was performed. The therapeutic effect by histological examination showed Grade 3 in the primary site and Grade 2 in both resional lymph nodes and liver metastasis.
报告了1例经EAP疗法成功治疗的产甲胎蛋白胃癌病例，并对相关文献进行了回顾。一名56岁男性因上腹部疼痛和背痛入院。经内镜检查和计算机断层扫描，他被诊断为患有伴有多发肝转移的胃癌。血清甲胎蛋白水平为2791000 ng/ml，活检标本通过过氧化物酶抗过氧化物酶（PAP）法在类肝结构中显示甲胎蛋白阳性肿瘤细胞。术前使用依托泊苷、阿霉素和顺铂进行联合化疗，导致血清甲胎蛋白水平显著下降。进行了次全胃切除术（R3）并进行了肝动脉插管。组织学检查显示原发部位疗效为3级，区域淋巴结和肝转移灶疗效均为2级。
