Sadahiro Sotaro, Suzuki Toshiyuki, Ishikawa Kenji, Maeda Yuji, Saguchi Takeshi, Yasuda Seiei, Makuuchi Hiroyasu, Murayama Chieko, Yamamoto Takaaki
Dept. of Gastrointestinal Surgery, Tokai University Hospital.
Gan To Kagaku Ryoho. 2002 Nov;29(11):2013-8.
One patient with pulmonary metastasis from colon cancer and one with para-aortic lymph node metastasis were treated with a combination of irinotecan and UFT. Irinotecan (100 mg/m2) was given by 24-hour intravenous infusion on day 1, and UFT (600 mg/day) was given orally on days 3 to 7 and days 10 to 14 of a 2-week course, which was then repeated. In the patient with pulmonary metastasis, the lesions in the lung resolved after 7 courses of chemotherapy. Surgery was performed after 10 courses. The patient with para-aortic lymph node metastasis had a partial response after 4 courses of chemotherapy, and underwent surgery after 6 courses. The only adverse effects were grade 2 myelosuppression and hair loss, none of which were severe enough to require treatment. With this chemotherapy regimen, patients are admitted for two days biweekly for 24-hour intravenous infusion of CPT-11. Thus, most of the treatment can be performed on an outpatient basis. The combination of irinotecan and UFT is expected to be useful for metastatic or recurrent colon cancer.
一名患有结肠癌肺转移的患者和一名患有主动脉旁淋巴结转移的患者接受了伊立替康和优福定的联合治疗。伊立替康（100mg/m²）在第1天通过24小时静脉输注给药，优福定（600mg/天）在为期2周的疗程的第3至7天和第10至14天口服，之后重复该疗程。在患有肺转移的患者中，经过7个疗程的化疗后肺部病变消退。在10个疗程后进行了手术。患有主动脉旁淋巴结转移的患者在4个疗程的化疗后出现部分缓解，并在6个疗程后接受了手术。唯一的不良反应是2级骨髓抑制和脱发，均未严重到需要治疗的程度。采用这种化疗方案，患者每两周住院两天，进行24小时伊立替康静脉输注。因此，大部分治疗可以在门诊进行。伊立替康和优福定的联合治疗有望对转移性或复发性结肠癌有效。
